BIAZZI-Standard-Pharma-Skid (BSPS)

[Hydrogenation Reaction Features]

[GMP Execution]

[Skid Mounted Plant]

[Gas/Liquid reactions]

[Processes offered]

[TDA]

[Polyol Derivatives]

[Benefits]

[R&D Test Centre]

[Competence Circle]

[Pharma Skid (BSPS)]

LET‘S TALK ABOUT THE
BIAZZI-STANDARD-PHARMA-SKID (BSPS)

• Multipurpose
• Modular
• Easy to operate
• Gas/liquid and liquid/liquid reactions

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at a glance:

• Operated in batch
• 50lt-250lt
• -1 to 10 barg max.
• from -20°C to 150°C
• Optimal heat transfer
• GMP-compliant
• CE conformance
• ATEX-conformance

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Why the BSPS ?

The pharmaceutical industry and mainly Custom Manufacturing Organization’s need a tool to be able to produce API’s and intermediates. These may require hydrogenation and/or other gas/liquid reactions, including catalyst-filtration, distillation, condensation and cover a wide range of conditions of the daily business in Pharma such as:

• batch operation
• temperature -20°C to 150°C
• pressure -1 barg up to 10 barg
• pH range 1 to 14
• slurry (solid/liquid/gas)
• multipurpose (e.g. various gas/liquid reactions)
• etc.

Additionally, the unit has to be available quickly and provide a cost-effective investment.

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Right TIME for the BSPS

With these objectives in mind, BIAZZI answered the call to develop a high end, multipurpose standardized offering, while also providing various options for customization. The Biazzi BSPS is an optimal production tool, easy to implement, effective, and available for a minimal capital investment.

BIAZZI is offering the following multipurpose batch wise operated gas-liquid plant, supplied as skid mounted unit. The plant enables to perform hydrogenation, oxidation, carbonylation and amination reactions. Beside Gas-Liquid-reactions and/or Liquid-Liquid-reactions can be run.

These process equipment and main process can be schematized as follows:

Operating conditions and properties of the BSPS:

• 50lt – 250lt useful
• -20/150°C
• -1/10 barg
• Material of construction: Hastelloy C22
• cGMP compliant CE-marking
• Clear separation between process and utility sides
• Gas aspiring turbine providing high mass-transfer
• Complete unit to perform Gas-Liquid and/or Liquid-Liquid-reactions including solvent reflux/distillation

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The BSPS is designed for

Products:

Active pharmaceutical ingredients and/or intermediates in aqueous solution or in solvents.

Solvents:

Most common solvents that can be used are:

Catalysts:

Typical heterogeneous catalysts used for gas-liquid reactions:

• Sponge metal-type catalysts
• Noble metal-type catalysts
• Etc.

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SUPPLIED BSPS

Scope of supply of the BSPS-BASIS-MODEL

• SKID-Mounted Unit with all valving, piping, insulation and instrumentation
• All equipment needed for gas/liquid or liquid/liquid reactions:
• Reactor with turbine agitator
• Containment device for raw material / catalyst feeding
• Heating / cooling system
• Condenser for solvent reflux or distillation
• Control system (hardware + program) with local control panel (HMI)
• Engineering documentation (P&ID's, specifications, FS, etc.)
• Validation (FAT + IQ/OQ)
• Technical documentation (operating and maintenance instructions, CE marking)

BSPS-Basis model. Dimensions: 2.2m (L) x 2.2m (W) x 3.2m (H)

Options available for the BSPS

• Preparation vessel
• Filtration system
• Sampling valve
• Off-gas scrubbing system

BSPS-All options model. Dimensions: 3.1m (L) x 2.2m (W) x 3.2m (H)

A TOOL, TO LET GROW YOUR SUCCESS !

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YOU WANT MORE? TELL US...

Please contact us:

1. Complete the contact form
2. Fill in the "Subject" field: BSPS
3. Fill in the "Message" field: Please send me an offer for the BSPS

or contact us by phone:
+41 21 989 21 21